Chen Lab Single-Cell Multi-Omics and Leukemia Research

Featured publications

2025

Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome
Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcome
Changya Chen, Jason Xu, Jonathan H. Sussman, Tiffaney Vincent, Joseph S. Tumulty, …, David Frank, Jun J. Yang, Kathrin M. Bernt, David T. Teachey, Kai Tan
Blood  ·  05 Jun 2025  ·  doi:10.1182/blood.2024027270

2024

A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia
Jason Xu, Changya Chen, Jonathan H. Sussman, Satoshi Yoshimura, Tiffaney Vincent, …, Kathrin Bernt, Jun J. Yang, Charles G. Mullighan, Kai Tan, David T. Teachey
Nature Cancer  ·  25 Nov 2024  ·  doi:10.1038/s43018-024-00863-5

2022

Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell like blasts in i KMT2A i -rearranged leukemia
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell–like blasts in KMT2A -rearranged leukemia
Changya Chen, Wenbao Yu, Fatemeh Alikarami, Qi Qiu, Chia-hui Chen, …, Patrick A. Brown, Erin M. Guest, David M. Barrett, Kathrin M. Bernt, Kai Tan
Blood  ·  07 Apr 2022  ·  doi:10.1182/blood.2021013442

2021

Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy
Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy
Gregory M. Chen, Changya Chen, Rajat K. Das, Peng Gao, Chia-Hui Chen, …, Qin Zhu, Regina M. Myers, Stephan A. Grupp, David M. Barrett, Kai Tan
Cancer Discovery  ·  05 Apr 2021  ·  doi:10.1158/2159-8290.CD-20-1677

2019

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells
Changya Chen, Wenbao Yu, Joanna Tober, Peng Gao, Bing He, Kiwon Lee, Tuan Trieu, Gerd A. Blobel, Nancy A. Speck, Kai Tan
Cell Reports  ·  01 Dec 2019  ·  doi:10.1016/j.celrep.2019.11.065

2015

A microfluidic device for epigenomic profiling using 100 cells
A microfluidic device for epigenomic profiling using 100 cells
Zhenning Cao, Changya Chen, Bing He, Kai Tan, Chang Lu
Nature Methods  ·  27 Jul 2015  ·  doi:10.1038/nmeth.3488